Chemical laboratory safety procedure; Purpose
Chemical laboratory safety procedure, The tenacity of this SOP is to define the general laboratory safety procedure, which will confirm the safe working condition within the Quality Control Laboratory.
Chemical laboratory safety procedure; Scope
This practice is valid for laboratory operations in the quality control laboratory of XX Pharmaceuticals Limited.
Definition
[] MSDS: Material safety data sheet.
[] PPE: Personal protective equipment.
[] QC: Quality Control.
[] SOP: Standard Operating Procedure.
Responsibilities:
The roles and responsibility is as follows
User/Analyst
[] To use personal PPE [Protective Equipment] as per MSDS [Material safety data sheet].
[] To maintain appropriate procedure for safety.
Manager, Quality Control
- To confirm that this procedure is kept up to date.
- To check that SOP reflects required working practices.
- To organize training on the SOP to all concerned personnel.
- To confirm implementation of the SOP after training.
- To achieve the operational control.
- To confirm the availability of suitable PPE & safety equipment.
Head of Quality Assurance
- Take initiative to Approval of the SOP.
- To confirm the overall implementation of the SOP.
Procedure:
Precaution(s):
- Take a note of material hazard facts from the supplier’s information. Review any relevant hazard data in MSDS.
- Do not smoke, drink, chew gum, eat, or apply cosmetics in the laboratory.
- Do not keep food or beverages in the laboratory.
- Always keep the flammable chemicals away from sources of fire.
- Try to avoid unnecessary chemical exposure.
- Never use fume hood for storage.
General procedure
- Wear laboratory coat and dedicated laboratory shoes, before entering into the laboratory. Keep goggles/ eye protector in the pocket of lab coat and & when necessary. This will give protection against corrosive action of chemicals & contaminations.
- Check PPE prior to use & attire appropriate protective equipment as processes dictate & when required to avoid chemical exposure.
- Wear gloves when using any type of hazardous or toxic chemicals & respirator when handling solvents.
- Wash & clean gloves regularly during a hazardous job. Discard soiled gloves as hazardous waste after use. Remove them before leaving laboratory/at the end of the work.
- When handling/transferring solid chemicals only from one container to another, wear gloves dust mask and activity to be perform under fume cupboard.
- Treat anonymous chemicals as hazardous & before starting work, make sure the analysts are familiar with all known hazards of the chemicals & take proper precautions.
- Reject glass apparatus that is damaged, cracked/even scratched.
- Examine all glassware before use. Use washed & clean glassware. Always move gas cylinder on cylinder trolley. Gas cylinder when standing upright position should always be appropriately supported.
- Use fume hood to handle hazardous chemicals, volatile liquid and flammable compounds.
- If solvent extraction is perform by shaking in a separating funnel, release pressure at frequent intervals by reversing funnel. Point the funnel away from the eyes & naked flames.
- Avoid pipetting anything by mouth. Use mechanical pipetting device/pipette bulb/ aspirator.
- Always add the acid to the water when diluting acids; never add water to acid. Add the acid to water slowly.
- Conduct periodical inspection in laboratory refrigerators & storerooms, correctly label all collected samples.
- Confirm all electrical wires are properly insulated. Report all electrical faults to the reporting authority/supervisor.
- Instantly Report all type accidents to the Supervisor/Manager.
- Confirm that all personnel engage laboratory know about the fire exit from the chemical laboratory.
- Confirm eye showers & Fire extinguishers are located at easily accessible points.
- Confirm all personnel/user are aware about the locations & proper use of all safety equipments (e.g. eye shower, First-aid kit, fire extinguishers).
- Wash hands before leaving the laboratory, in case of chemical handling.
- Wash the exposed area with large amount of water in case of spillage of any acid, base or irritant material on skin and seek immediate medical support if required.
- Clearly sealed& labeled the dangerous materials and never leave it on the working bench unattended
- Visitors to laboratory should be under the direct supervision of a accountable personnel.
Spillages
- Spillages must be instantly dealt as per SOP for Handling of Spillages in the QC Laboratory.
Disposal of waste
- Waste must be disposed as per SOP for Waste Management in QC Laboratory.